The Marriott-San Diego Mission Valley is a little over a mile walking distance from the stadium. A lot of local people park on this street and walk to the stadium. The other hotels are a longer walk or a short ride on the trolley.
The Super 8 San Diego/ Mission Valley Area is also about the same distance in the other direction. This hotel is basically next to a traffic circle.
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The problem with Mission Valley hotels is that they can get extremely expensive if there is multiple things happening at once in the city. The Marriot may be more of what you are looking for, but sometimes even the Super 8 is hundreds of dollars per night.
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Someone mentioned the DoubleTree. This is a long walk, but it is located in a nice shopping center with a Joe's Crab Shack, Movie Theaters, Coffee shops, and bookstores. There is a trolley stop right nearby. I would choose to stay there over the Marriot and take the trolley.
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